三七皂苷Rg1对犬心脏电生理特性及心室颤动阈值的影响。
Effects of Panax notoginseng saponin Rg1 on cardiac electrophysiological properties and ventricular fibrillation threshold in dogs.
作者信息
Wu W, Zhang X M, Liu P M, Li J M, Wang J F
机构信息
Department of Internal Medicine, Sun Yat-Sen University of Medical Sciences, Guangzhou, China.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Sep;16(5):459-63.
AIM
To study the effects of Rg1 isolated from saponins of Panax notoginseng on cardiac electrophysiological properties and ventricular fibrillation threshold (VFT).
METHODS
Seventeen open-chest dogs were randomly allocated into a Rg1 group (20 mg kg-1, iv) and a control group. The electrophysiological variables and VFT were evaluated by standard electric stimuli and monophasic action potential (MAP) recording.
RESULTS
Rg1 prolonged sinus node recovery time (SNRT) by 19.1%, AV conduction Wenckebach cycle length (AVWCL) by 7.1%, and ventricular effective refractory period (VERP) by 7.9%. It prolonged ventricular MAPD30, MAPD50, and MAPD90 by 25.5%, 24.2%, and 13.5%, respectively. VFT was increased by 19.2%.
CONCLUSION
Rg1 prolonged ventricular refractoriness and repolarization, and increased VFT. It was indicated that cardiac electrophysiological effects of Rg1 were similar to those of amiodarone.
目的
研究从三七皂苷中分离得到的人参皂苷Rg1对心脏电生理特性和室颤阈值（VFT）的影响。
方法
将17只开胸犬随机分为人参皂苷Rg1组（20 mg·kg-1，静脉注射）和对照组。通过标准电刺激和单相动作电位（MAP）记录评估电生理变量和VFT。
结果
人参皂苷Rg1使窦房结恢复时间（SNRT）延长19.1%，房室传导文氏周期长度（AVWCL）延长7.1%，心室有效不应期（VERP）延长7.9%。它分别使心室MAPD30、MAPD50和MAPD90延长25.5%、24.2%和13.5%。VFT增加19.2%。
结论
人参皂苷Rg1延长心室不应期和复极化，并增加VFT。表明人参皂苷Rg1的心脏电生理作用与胺碘酮相似。
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