Physical Education College, Zhengzhou University, Zhengzhou, China.
Indian J Med Res. 2013 Jan;137(1):151-5.
BACKGROUND & OBJECTIVES: Several biological activities of total saponins of Radix notoginseng (TSRN), a traditional Chinese medicine, have been reported. The present study was carried out to investigate anti-fatigue activity of TSRN in male Kunming mice.
Mice were divided into four groups. The first group designated as control group was administered with distilled water by gavage every day. The second, third and fourth groups designated as TSRN treatment groups were administered with TSRN of 20, 40 and 80 mg/kg body weight/day, respectively. The treatment continued for 28 days. Exhaustive swimming time, blood lactate and tissue glycogen contents of mice after swimming were determined.
TSRN extended exhaustive swimming time of mice, effectively delayed the increase of lactate in the blood, as well as increased the tissue glycogen contents.
INTERPRETATION & CONCLUSIONS: TSRN showed promising anti-fatigue activity in animal model. However, further study is needed to elucidate the mechanism of the effect of TSRN on fatigue.
已有研究报道，中药三七总皂苷具有多种生物活性。本研究旨在探讨三七总皂苷（TSRN）对雄性昆明小鼠的抗疲劳作用。
将小鼠分为 4 组，对照组每天灌胃给予蒸馏水，TSRN 低、中、高剂量组分别灌胃给予 20、40 和 80mg/kg 体重的 TSRN，连续 28 天。测定各组小鼠的力竭游泳时间、游泳后血乳酸和组织糖原含量。
TSRN 延长了小鼠的力竭游泳时间，有效延缓了血乳酸的升高，同时增加了组织糖原含量。
TSRN 在动物模型中表现出有希望的抗疲劳活性。然而，需要进一步的研究来阐明 TSRN 对疲劳作用的机制。
