Na H S, Kim Y I, Yoon Y W, Han H C, Nahm S H, Hong S K
Department of Physiology, Korea University College of Medicine, Seoul, Korea.
Am Heart J. 1996 Jul;132(1 Pt 1):78-83. doi: 10.1016/s0002-8703(96)90393-2.
With a cat model of regional cardiac ischemia, we examined whether the incidence of reperfusion-induced ventricular fibrillation (VF) could be reduced by ventricular premature beat (VPB)-driven intermittent reperfusion. In addition, we assessed whether the effect of the intermittent reperfusion was comparable with that of ischemic preconditioning in suppressing the VF. Of 15 cats subjected to uninterrupted reperfusion after 20-minute occlusion of the left anterior descending coronary artery, 13 (86.70%) had VF, whereas only 1 (7.1%) of 14 cats subjected to the VPB-driven intermittent reperfusion had VF. This incidence of VF was significantly lower than that of the animal group subjected to uninterrupted reperfusion. However, it was not statistically different from that (3 of 15) of the group subjected to a 10-minute episode of the coronary artery occlusion before the 20-minute occlusion (i.e., "ischermic preconditioning"). Our results suggest that the VPB-driven intermittent reperfusion (i.e., "postconditioning") is very effective in preventing reperfusion-induced VF and as good as, if not better than, ischemic preconditioning.
利用局部心肌缺血的猫模型，我们研究了室性早搏（VPB）驱动的间歇性再灌注是否能降低再灌注诱导的室颤（VF）发生率。此外，我们评估了间歇性再灌注在抑制室颤方面的效果是否与缺血预处理相当。在左冠状动脉前降支闭塞20分钟后进行不间断再灌注的15只猫中，13只（86.70%）发生了室颤，而在接受VPB驱动的间歇性再灌注的14只猫中，只有1只（7.1%）发生了室颤。这种室颤发生率显著低于接受不间断再灌注的动物组。然而，它与在20分钟闭塞前先进行10分钟冠状动脉闭塞（即“缺血预处理”）的组（15只中有3只）的发生率在统计学上没有差异。我们的结果表明，VPB驱动的间歇性再灌注（即“后处理”）在预防再灌注诱导的室颤方面非常有效，且即便不比缺血预处理更好，也与之一样有效。
