Seredenin S B, Semenova T P, Kozlovskaia M M, Medvinskaia N I, Nezovibat'ko V N
Eksp Klin Farmakol. 1995 Nov-Dec;58(6):3-6.
The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine. Intracutaneous administration of both peptides (300 micrograms/kg) was found to result in weakening perception of stress situations; an increase in stability of investigation behavior and normalization of serotonin level in the brain of rats with chronic deprivation of serotoninergic system activity. Anxiolytic and psychostimulant activities of TP-7 are more pronounced than those of tafcine.
在95只新生时给予5,7-二羟基色胺的成年雄性Wistar大鼠中，研究了tafcin（苏氨酸-赖氨酸-脯氨酸-精氨酸）及其类似物TP-7（苏氨酸-赖氨酸-脯氨酸-精氨酸-脯氨酸-甘氨酸-脯氨酸）对大鼠行为和血清素脑交换的影响。发现皮内注射这两种肽（300微克/千克）可减弱对应激情况的感知；增强具有慢性血清素能系统活性剥夺的大鼠的探究行为稳定性并使大脑血清素水平正常化。TP-7的抗焦虑和精神兴奋活性比tafcin更明显。
