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正常人和神经症患者对心理应激的催乳素和生长激素反应。

Prolactin and growth hormone responses to psychological stress in normal and neurotic subjects.

作者信息

Miyabo S, Asato T, Mizushima N

出版信息

J Clin Endocrinol Metab. 1977 May;44(5):947-51. doi: 10.1210/jcem-44-5-947.

DOI:10.1210/jcem-44-5-947
PMID:870518
Abstract

In order to study the response of plasma prolactin (PRL) to acute psychological stress and to compare it with that of growth hormone (GH), the mirror drawing test (MDT) was performed in 20 normal controls (11 male, 9 female) and 22 neurotic patients (12 male, 10 female). Plasma PRL and GH were measured serially before, during and after the test. In controls, the test caused no significant change in plasma levels of either hormone. In neurotic males, the response of PRL to the test was not consistent, whereas, in neurotic females, plasma PRL level rose significantly following the test. Increase of GH, on the other hand, was apparent in the neurotics of both sexes. The correlation between the responses of the two hormones in the neurotics was low and non-significant. The results indicate that although the psychoendocrine coping mechanism in the neurotics works less effectively for both PRL and GH, the two hormones may have different psychological correlates.

摘要

为了研究血浆催乳素(PRL)对急性心理应激的反应,并将其与生长激素(GH)的反应进行比较,对20名正常对照者(11名男性,9名女性)和22名神经症患者(12名男性,10名女性)进行了镜像绘画测试(MDT)。在测试前、测试期间和测试后连续测量血浆PRL和GH。在对照组中,测试未引起两种激素血浆水平的显著变化。在神经症男性中,PRL对测试的反应不一致,而在神经症女性中,测试后血浆PRL水平显著升高。另一方面,GH的升高在两性神经症患者中均很明显。神经症患者中两种激素反应之间的相关性较低且无统计学意义。结果表明,尽管神经症患者的心理内分泌应对机制对PRL和GH的作用均不太有效,但这两种激素可能具有不同的心理关联。

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