Biernat W, Woźniak L
Department of Tumor Pathology, Medical University, Lódź.
Pol J Pathol. 1996;47(1):3-6.
We analyzed the expression of p53 in 74 cutaneous adnexal tumors, with enhancement of the detection by incubation of the slides in the microwave. The immunostaining in benign tumors was almost uniformly negative as we found p53-positivity only in one poroma, one nodular hidradenoma, and one case of syringocystadenoma papilliferum (amongst 13 spiradenomas, 9 cylindromas, 12 nodular hidradenomas, 7 poromas, 6 syringomas, 7 syringocystadenomas papilliferum, 2 papillary tubular adenomas and 4 chondroid syringomas). These results contrasted with the widespread p53 overexpression, which was revealed in the sweat gland carcinomas. All spiradenocarcinomas (3), malignant nodular hidradenoma (1), apocrine hidradenocarcinoma (1), and malignant syringoadenoma (1) showed a strong reaction to anti-p53 antibody. Two of three eccrine hidradenocarcinomas, and two of three porocarcinomas presented p53 overexpression, whereas in one case of malignant cylindroma and adenoid cystic carcinoma we did not find p53-positivity. The results of the study indicate an important role, that p53 protein plays in the malignant sweat gland tumors in comparison to their benign counterparts, but reveal that its overexpression may also occur in the reactive and benign neoplastic processes.
我们分析了74例皮肤附属器肿瘤中p53的表达情况，通过将玻片置于微波炉中孵育来增强检测效果。在良性肿瘤中，免疫染色几乎均为阴性，因为我们仅在1例汗孔瘤、1例结节性汗腺瘤和1例乳头状汗管囊腺瘤中发现p53阳性（在13例螺旋腺瘤、9例圆柱瘤、12例结节性汗腺瘤、7例汗孔瘤、6例汗腺瘤、7例乳头状汗管囊腺瘤、2例乳头管状腺瘤和4例软骨样汗腺瘤中）。这些结果与在汗腺癌中发现的广泛p53过表达形成对比。所有螺旋腺癌（3例）、恶性结节性汗腺瘤（1例）、大汗腺癌（1例）和恶性汗腺腺瘤（1例）对抗p53抗体均呈强反应。3例小汗腺癌中的2例以及3例汗孔癌中的2例呈现p53过表达，而在1例恶性圆柱瘤和腺样囊性癌病例中未发现p53阳性。研究结果表明，与良性皮肤附属器肿瘤相比，p53蛋白在恶性汗腺肿瘤中起重要作用，但也表明其过表达也可能出现在反应性和良性肿瘤形成过程中。
