Biemat W, Kordek R, Woźniak L
Laboratories of Tumor Biology, Medical University, Lódź.
Pol J Pathol. 1996;47(1):7-11.
We studied the presence of myoepithelial cells (MCs) in the benign and malignant sweat gland adenomas by immunostaining with antibody to alpha-smooth muscle actin. We found peripheral arrangement of MCs in the neoplastic nests in cutaneous cylindromas (9), spiradenomas (13), syringoadenomas (7), and one case of adenoid cystic carcinoma. Dispersed MCs were identified in some cases of nodular hidradenoma (7/13) and malignant portion of spiradenocarcinoma (2/3). The remnants of the peripheral arrangement of MCs were retained in the benign part in cylindrocarcinoma and every case of spiradenocarcinoma, likewise in composed malignant adnexoma (malignisation within cylindroma/spiradenoma). We could not find MCs in papillary eccrine adenoma (2), poromas (7) and porocarcinomas (3), syringomas (6), chondroid syringomas (3), malignant nodular hidradenoma (1) and malignant portion of syringoadenoma (1). In one of three cases of eccrine hidradenocarcinoma focal myoepithelial differentiation could be identified at the periphery of the epithelial nests. These results confirm heterogeneity of the differentiation in sweat gland tumors, emphasizing the validity of division of those tumors into those with the differentiation towards secretory and ductal portion of the gland. The former group demonstrates the variability of arrangement of myoepithelial cells depending on the degree of dedifferentiation of the developing carcinoma. These cells may be replaced by outgrowing tumor, but may also accompany the neoplastic growth. Less significant is the presence of the MCs in the adenomas with ductal differentiation, which either in benign and malignant tumors may be lacking. The variability of MCs occurrence in cutaneous adenomas and carcinomas precludes its significance as a solitary factor in the differentiation between benign and malignant proliferations.
我们通过用抗α平滑肌肌动蛋白抗体进行免疫染色，研究了良性和恶性汗腺腺瘤中肌上皮细胞（MCs）的存在情况。我们发现，在皮肤圆柱瘤（9例）、螺旋腺瘤（13例）、汗腺腺瘤（7例）以及1例腺样囊性癌的肿瘤巢中，MCs呈周边排列。在一些结节性汗腺瘤（7/13）和螺旋腺癌的恶性部分（2/3）中，发现有散在的MCs。圆柱癌的良性部分以及每例螺旋腺癌中，MCs周边排列的残余部分得以保留，同样在复合性恶性附属器肿瘤（圆柱瘤/螺旋腺瘤内恶变）中也是如此。我们在乳头状小汗腺腺瘤（2例）、汗孔瘤（7例）、汗孔癌（3例）、汗腺导管瘤（6例）、软骨样汗腺导管瘤（3例）、恶性结节性汗腺瘤（1例）以及汗腺腺瘤的恶性部分（1例）中未发现MCs。在3例小汗腺癌中的1例，在上皮巢周边可识别出局灶性肌上皮分化。这些结果证实了汗腺肿瘤分化的异质性，强调了将这些肿瘤分为向腺体分泌部和导管部分化的肿瘤的有效性。前一组显示了肌上皮细胞排列的变异性，这取决于发展中的癌的去分化程度。这些细胞可能被生长的肿瘤所取代，但也可能伴随肿瘤生长。在具有导管分化的腺瘤中，MCs的存在不太显著，在良性和恶性肿瘤中都可能缺乏。皮肤腺瘤和癌中MCs出现情况的变异性排除了其作为良性和恶性增殖分化的单一因素的意义。
