Wierzba-Bobrowicz T, Gwiazda E, Poszwińska Z
Department of Neuropathology, Institute of Psychiatry and Neurology, Warszawa.
Folia Neuropathol. 1995;33(2):77-83.
To assess the cytogenesis and the structure of the microglial cells, we studied mesencephalons in 47 human fetuses at 7th-40th week of gestational age, and in 18 adult brains from 20 to 70 years. The microglial cells were identified and characterized by morphological criteria using immunohistochemical and histochemical techniques. As early as in the 8th week of gestational age RCA-1 positive cells were detected, mainly in form of amoeboid microglial cells. These microglial cells were observed around the germinal matrix, and at or near the wall of blood vessels. RCA-1 positive cells which were detected within leptomeninges were large but without processes. At the 16th-40th week of gestational age we observed in mesencephalon, amoeboid microglial cells, and also RCA-1 positive and ferritin reactive ramified microglial cells.
为了评估小胶质细胞的细胞发生及结构，我们研究了47例孕龄在7至40周的人类胎儿的中脑，以及18例年龄在20至70岁的成人大脑。通过免疫组织化学和组织化学技术，依据形态学标准对小胶质细胞进行识别和特征描述。早在孕龄第8周时，就检测到了RCA-1阳性细胞，主要呈阿米巴样小胶质细胞形式。这些小胶质细胞见于生发基质周围以及血管壁处或其附近。在软脑膜内检测到的RCA-1阳性细胞体积较大但无突起。在孕龄第16至40周时，我们在中脑中观察到了阿米巴样小胶质细胞，以及RCA-1阳性和铁蛋白反应性的分支状小胶质细胞。
