Peters H D, Peskar B A, Schönhöfer P S
Naunyn Schmiedebergs Arch Pharmacol. 1977;297 Suppl 1:S89-93. doi: 10.1007/BF00587790.
Prostaglandins (PGs) are synthesized by cultured fibroblasts. PGs regulate specific cellular functions by influencing cyclic nucleotide levels. PGE1 increases cAMP levels, thus enhancing glycosaminoglycan (GAG) synthesis and reducing proliferation. Exogenous cyclic nucleotides, on the other hand, affect PG formation. Glucocorticoids (GCs) decrease cAMP content, GAG synthesis and PG formation in fibroblasts, the latter effect occurring only after prolonged incubations. The decrease in endogenous PG levels causes a sensitization of the cells to exogenous PGE1, thus counteracting the initial inhibitory effect of GCs on cAMP content and GAG synthesis. Cell proliferation shows an inverse relationship to PG-induced changes in cAMP levels.
前列腺素（PGs）由培养的成纤维细胞合成。PGs通过影响环核苷酸水平来调节特定的细胞功能。前列腺素E1（PGE1）可提高环磷酸腺苷（cAMP）水平，从而增强糖胺聚糖（GAG）的合成并减少细胞增殖。另一方面，外源性环核苷酸会影响PG的形成。糖皮质激素（GCs）可降低成纤维细胞中的cAMP含量、GAG合成及PG形成，后者的作用仅在长时间孵育后出现。内源性PG水平的降低会使细胞对外源性PGE1敏感，从而抵消GCs对cAMP含量和GAG合成的初始抑制作用。细胞增殖与PG诱导的cAMP水平变化呈负相关。
