前列腺素F2α诱导培养的小鼠成纤维细胞增殖
Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha.
作者信息
De Asua L J, Clingan D, Rudland P S
出版信息
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2724-8. doi: 10.1073/pnas.72.7.2724.
Abstract
Prostaglandin (PG) F2alpha added to quiescent Swiss mouse 3T3 cell cultures initiates DNA synthesis and cell proliferation in a small proportion of the cells. Insulin, which markedly potentiates the effect of PGF2alpha on the initiation of cell division when added with PGF2alpha, causes a simultaneous reduction in intracellular cyclic AMP and an increase in cyclic GMP concentrations similar to those observed after serum addition. Prostaglandins E1 and E2 are less effective than PGF2alpha in initiating DNA synthesis and this effect is only observed at higher concentrations. Therefore, some prostaglandins can act as extracellular factors to regulate cell proliferation.
摘要
添加到静止的瑞士小鼠3T3细胞培养物中的前列腺素（PG）F2α可在一小部分细胞中启动DNA合成和细胞增殖。胰岛素与PGF2α一起添加时，能显著增强PGF2α对细胞分裂启动的作用，导致细胞内环磷酸腺苷（cAMP）同时减少，环磷酸鸟苷（cGMP）浓度增加，这与添加血清后观察到的情况相似。前列腺素E1和E2在启动DNA合成方面不如PGF2α有效，且这种作用仅在较高浓度下才会观察到。因此，一些前列腺素可作为细胞外因子来调节细胞增殖。
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