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1
Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha.前列腺素F2α诱导培养的小鼠成纤维细胞增殖
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2724-8. doi: 10.1073/pnas.72.7.2724.
2
Prostaglandins E1 and E2 interact with prostaglandin F2alpha to regulate initiation of DNA replication and cell division in swiss 3T3 cells.前列腺素E1和E2与前列腺素F2α相互作用，以调节瑞士3T3细胞中DNA复制的起始和细胞分裂。
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Prostaglandins E1 and E2 interact with prostaglandin F2alpha to regulate initiation of DNA replication and cell division in swiss 3T3 cells.前列腺素E1和E2与前列腺素F2α相互作用，以调节瑞士3T3细胞中DNA复制的起始和细胞分裂。
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9
Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells.多种促有丝分裂因子可诱导静止鸡细胞中两种相关的42000道尔顿蛋白质的酪氨酸磷酸化。
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Spontaneous production of thymocyte-activating factor by human gingival fibroblasts and its autoregulatory effect on their proliferation.人牙龈成纤维细胞自发产生胸腺细胞激活因子及其对自身增殖的自调节作用。
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本文引用的文献

1
Prostaglandin levels in normal and transformed baby-hamster-kidney fibroblasts.正常及转化的幼仓鼠肾成纤维细胞中的前列腺素水平。
Nat New Biol. 1973 May 9;243(123):50-1.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
The initiation of cell division in a contact-inhibited mammalian cell line.接触抑制的哺乳动物细胞系中细胞分裂的起始
J Cell Physiol. 1965 Dec;66(3):325-33. doi: 10.1002/jcp.1030660310.
4
Vasoactive substances in Kaposi's sarcoma.卡波西肉瘤中的血管活性物质。
Cancer. 1971 Jan;27(1):233-7. doi: 10.1002/1097-0142(197101)27:1<233::aid-cncr2820270133>3.0.co;2-q.
5
Indomethacin and aspirin abolish prostaglandin release from the spleen.吲哚美辛和阿司匹林可抑制前列腺素从脾脏释放。
Nat New Biol. 1971 Jun 23;231(25):237-9. doi: 10.1038/newbio231237a0.
6
Control of growth of a tumor cell by linoleic acid.亚油酸对肿瘤细胞生长的控制
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3976-8. doi: 10.1073/pnas.71.10.3976.
7
Membrane fatty acid replacements and their effect on growth and lectin-induced agglutinability.膜脂肪酸替代物及其对生长和凝集素诱导的凝集性的影响。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3115-9. doi: 10.1073/pnas.71.8.3115.
8
Do cells cycle?细胞会进行周期循环吗？
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1263-7. doi: 10.1073/pnas.70.4.1263.
9
Prostaglandin production by experimental tumours and effects of anti-inflammatory compounds.
Nat New Biol. 1972 May 10;237(71):59-61. doi: 10.1038/newbio237059a0.
10
Studies of prostaglandins in rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene.关于7,12-二甲基苯并(a)蒽诱导的大鼠乳腺肿瘤中前列腺素的研究。
Cancer Res. 1974 Dec;34(12):3229-31.

前列腺素F2α诱导培养的小鼠成纤维细胞增殖

Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha.

作者信息

De Asua L J, Clingan D, Rudland P S

出版信息

Proc Natl Acad Sci U S A. 1975 Jul;72(7):2724-8. doi: 10.1073/pnas.72.7.2724.

DOI:10.1073/pnas.72.7.2724
PMID:170616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432843/
Abstract

Prostaglandin (PG) F2alpha added to quiescent Swiss mouse 3T3 cell cultures initiates DNA synthesis and cell proliferation in a small proportion of the cells. Insulin, which markedly potentiates the effect of PGF2alpha on the initiation of cell division when added with PGF2alpha, causes a simultaneous reduction in intracellular cyclic AMP and an increase in cyclic GMP concentrations similar to those observed after serum addition. Prostaglandins E1 and E2 are less effective than PGF2alpha in initiating DNA synthesis and this effect is only observed at higher concentrations. Therefore, some prostaglandins can act as extracellular factors to regulate cell proliferation.

摘要

添加到静止的瑞士小鼠3T3细胞培养物中的前列腺素（PG）F2α可在一小部分细胞中启动DNA合成和细胞增殖。胰岛素与PGF2α一起添加时，能显著增强PGF2α对细胞分裂启动的作用，导致细胞内环磷酸腺苷（cAMP）同时减少，环磷酸鸟苷（cGMP）浓度增加，这与添加血清后观察到的情况相似。前列腺素E1和E2在启动DNA合成方面不如PGF2α有效，且这种作用仅在较高浓度下才会观察到。因此，一些前列腺素可作为细胞外因子来调节细胞增殖。