Nance D M, Shryne J E, Gordon J H, Gorski R A
Pharmacol Biochem Behav. 1977 Feb;6(2):227-34. doi: 10.1016/0091-3057(77)90078-8.
Various experimental parameters related to the effects of septal lesions on the lordosis behavior of rats have been examined. First, the failure of septal lesions to facilitate lordosis behavior in male rats appears to be related to the degree of exposure to androgens neonatally. The normal facilitation in lordosis behavior associated with septal destruction in adult female rats does not occur if these female rats are treated with 1.0 mg of testosterone propionate (TP) on Day 1 of life. Yet female rats given 270 mug of TP on Day 3 of life respond the same as do normal females to septal lesions. Second, these sexually dimorphic effects of septal lesions can be modified in adult rats by chronic treatment with gonadal hormones following septal destruction. Whereas previous studies indicated that chronic estrogen injections permit a facilitation in lordosis behavior to occur in septal lesioned male rats, the present results showed that chronic injections of TP following a septal lesion attenuates the facilitation in lordosis behavior typically observed in adult female rats following a septal lesion. Third, examination of the time course for the facilitation in lordosis behavior following a septal lesion revealed a four to six day delay before the appearance of heightened female sexual behavior. Fourth, in support of the possibility that modifications in lordosis behavior by septal lesions may be mediated by a depletion or imbalance in brain amines, amphetamine was found to reduce the high levels of lordosis behavior of septal lesioned female rats to control levels. Finally, further evidence of a potential role for brain amines in the effects of septal lesions was provided by the observation of significantly lower content and turnover of dopamine in the amygdala of septal lesioned female rats, relative to sham operated controls.
已对与隔区损伤对大鼠脊柱前凸行为的影响相关的各种实验参数进行了研究。首先，隔区损伤未能促进雄性大鼠的脊柱前凸行为，这似乎与新生期雄激素的暴露程度有关。如果成年雌性大鼠在出生第1天接受1.0毫克丙酸睾酮（TP）治疗，那么与成年雌性大鼠隔区破坏相关的正常脊柱前凸行为促进作用就不会出现。然而，在出生第3天给予270微克TP的雌性大鼠对隔区损伤的反应与正常雌性大鼠相同。其次，隔区损伤的这些性别差异效应在成年大鼠中可通过隔区破坏后性腺激素的长期治疗来改变。以往研究表明，长期注射雌激素可使隔区损伤的雄性大鼠出现脊柱前凸行为促进作用，而目前的结果显示，隔区损伤后长期注射TP会减弱成年雌性大鼠隔区损伤后通常观察到的脊柱前凸行为促进作用。第三，对隔区损伤后脊柱前凸行为促进作用的时间进程进行检查发现，在增强的雌性行为出现之前有4至6天的延迟。第四，为支持隔区损伤对脊柱前凸行为的改变可能由脑胺的耗竭或失衡介导这一可能性，发现苯丙胺可将隔区损伤雌性大鼠的高水平脊柱前凸行为降低至对照水平。最后，相对于假手术对照组，观察到隔区损伤雌性大鼠杏仁核中多巴胺含量和周转率显著降低，这为脑胺在隔区损伤效应中的潜在作用提供了进一步证据。
