Nance D M, Phelps C, Shryne J E, Gorski R A
Brain Res Bull. 1977 Jan-Feb;2(1):49-53. doi: 10.1016/0361-9230(77)90024-7.
Earlier experiments indicated that chronic exposure to estradiol benzoate (EB) following septal lesions can increase the subsequent levels of female sexual behavior in male rats tested several months later following priming doses of EB. However, the present study demonstrates that a single injection of a large dose of EB (50 microng) two days after septal destruction did not modify subsequent responsiveness to EB priming in male rats relative to sham operated controls. Yet male rats given 10 daily injections of 5.0 microng EB/day immediately following a septal lesion were more responsive to EB than oil treated controls when tested later for lordosis behavior. Therefore, the capacity for EB to alter the behavioral effects of septal lesions on lordosis behavior in male rats is related to both chronic administration and a period of susceptibility to some action of EB during the immediate post-lesion period. In two additional experiments, chronic hypothyroidism induced by propylthiouracil or thyroidectomy was also found to modify the effects of septal lesions on female sexual behavior of male rats. These latter results indicate that EB is not unique in its capacity to alter the behavioral effects of septal lesions in male rats, and are consistent with the view that both EB and hypothyroidism may interact with some dynamic process associated with recovery from brain lesions.
早期实验表明，在隔区损伤后长期暴露于苯甲酸雌二醇（EB），可使几个月后经EB预激发剂量测试的雄性大鼠的后续性行为水平升高。然而，本研究表明，在隔区破坏两天后单次注射大剂量EB（50微克），相对于假手术对照组，并未改变雄性大鼠对EB预激发的后续反应性。然而，在隔区损伤后立即每天注射10次、每次5.0微克EB的雄性大鼠，在后来测试其脊柱前凸行为时，比用油处理的对照组对EB更敏感。因此，EB改变隔区损伤对雄性大鼠脊柱前凸行为的行为学效应的能力，既与长期给药有关，也与损伤后即刻对EB某些作用的易感性时期有关。在另外两个实验中，还发现丙硫氧嘧啶或甲状腺切除术诱导的慢性甲状腺功能减退也会改变隔区损伤对雄性大鼠性行为的影响。后一组结果表明，EB改变雄性大鼠隔区损伤行为学效应的能力并非独一无二，并且与EB和甲状腺功能减退可能与与脑损伤恢复相关的一些动态过程相互作用的观点一致。
