Gordaliza M, Faircloth G T, Castro M A, Miguel del Corral J M, López-Vázquez M L, San Feliciano A
Laboratorio de Química, Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
J Med Chem. 1996 Jul 5;39(14):2865-8. doi: 10.1021/jm960023h.
The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'-demethyldeoxypodophyllotoxin (8), beta-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to their suppression of activated splenocytes.
通过T细胞介导的免疫反应首次证明了几种内酯型、非内酯型和杂环稠合环木脂素的免疫抑制活性。在所测试的化合物中，4'-去甲基脱氧鬼臼毒素（8）、β-阿朴基鬼臼苦素（6）以及异恶唑啉稠合环木脂素15在抑制活化脾细胞方面最为有效。
