DNA双链断裂修复功能可抵御细小病毒感染。
DNA double-strand break repair functions defend against parvovirus infection.
作者信息
Tauer T J, Schneiderman M H, Vishwanatha J K, Rhode S L
机构信息
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495, USA.
出版信息
J Virol. 1996 Sep;70(9):6446-9. doi: 10.1128/JVI.70.9.6446-6449.1996.
Abstract
We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.
摘要
我们在代表多种DNA修复缺陷的9种CHO细胞系中测量了细小病毒的复制情况以及对X射线损伤的敏感性。我们发现细小病毒的复制效率随放射敏感性增加而提高。在DNA修复功能正常的细胞中，细小病毒的复制在感染早期就被破坏，此时单链病毒DNA基因组尚未转化为双链复制形式。因此，DNA修复机制的状态与细小病毒复制呈负相关，并且与宿主修复X射线诱导损伤的能力成正比。
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本文引用的文献
1
Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants.Ku86定义了遗传缺陷，并恢复了X射线抗性以及V(D)J重组，以补充第5组仓鼠细胞突变体。
Mol Cell Biol. 1996 Apr;16(4):1519-26. doi: 10.1128/MCB.16.4.1519.
2
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors.第二链合成是重组腺相关病毒载体进行有效转导的限速步骤。
J Virol. 1996 May;70(5):3227-34. doi: 10.1128/JVI.70.5.3227-3234.1996.
3
Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis.用于基因治疗的重组腺相关病毒转导受前导链合成的限制。
J Virol. 1996 Jan;70(1):520-32. doi: 10.1128/JVI.70.1.520-532.1996.
4
The complete nucleotide sequence of parvovirus LuIII and localization of a unique sequence possibly responsible for its encapsidation pattern.细小病毒LuIII的完整核苷酸序列以及可能与其包装模式有关的独特序列的定位。
Virology. 1993 Jan;192(1):339-45. doi: 10.1006/viro.1993.1040.
5
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen.DNA依赖性蛋白激酶：对DNA末端的需求以及与Ku抗原的关联。
Cell. 1993 Jan 15;72(1):131-42. doi: 10.1016/0092-8674(93)90057-w.
6
Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.xrs双链DNA修复缺陷型突变体中缺乏Ku样DNA末端结合活性。
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