源自感染鼠γ-疱疹病毒68的小鼠的肿瘤细胞系的特性分析。
Characterization of tumor cell lines derived from murine gammaherpesvirus-68-infected mice.
作者信息
Usherwood E J, Stewart J P, Nash A A
机构信息
Department of Veterinary Pathology, University of Edinburgh, Summerhall, United Kingdom.
出版信息
J Virol. 1996 Sep;70(9):6516-8. doi: 10.1128/JVI.70.9.6516-6518.1996.
Abstract
Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.
摘要
细胞系源自患有鼠γ-疱疹病毒68（MHV-68）相关淋巴增殖性疾病的小鼠。其中四个细胞系的表型不明确且MHV-68呈阴性。一个名为S11的细胞系是B淋巴细胞，其含有线性和游离形式的MHV-68基因组并能释放病毒。该细胞系可克隆，并能在裸鼠体内长成肿瘤。这是首个产生的自然发生的MHV-68阳性B细胞系，它将成为研究MHV-68潜伏状态的宝贵工具。
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