月经周期与间质性膀胱炎中的尿表皮素（MUC-1糖蛋白）
Urinary epitectin (MUC-1 glycoprotein) in the menstrual cycle and interstitial cystitis.
作者信息
Erickson D R, Mast S, Ordille S, Bhavanandan V P
机构信息
Department of Surgery (Division of Urology), Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, USA.
出版信息
J Urol. 1996 Sep;156(3):938-42.
PURPOSE
We compared interstitial cystitis and control urine specimens for epitectin (MUC-1 glycoprotein), an epithelial mucin.
MATERIALS AND METHODS
Urinary epitectin was measured in 28 patients with interstitial cystitis and 26 healthy controls. Ten controls provided multiple urine samples to determine whether urinary epitectin changes with the menstrual cycle.
RESULTS
Epitectin levels were stable throughout the menstrual cycle. Interstitial cystitis cases had decreased urinary epitectin-to-creatinine ratios (mean 3.89 versus 6.38 micrograms./mg. creatinine for controls, p = 0.0035) and epitectin concentrations (mean 1.96 versus 4.30 micrograms./ml., respectively, p = 0.0005).
CONCLUSIONS
Decreased mean urinary epitectin levels may reflect a cause (epithelial mucin deficiency) or a consequence of interstitial cystitis.
目的
我们比较了间质性膀胱炎患者与对照尿液样本中的表位蛋白（MUC-1糖蛋白），一种上皮粘蛋白。
材料与方法
检测了28例间质性膀胱炎患者和26例健康对照者尿液中的表位蛋白。10名对照者提供了多个尿液样本，以确定尿液表位蛋白是否随月经周期变化。
结果
表位蛋白水平在整个月经周期中保持稳定。间质性膀胱炎患者尿液中表位蛋白与肌酐的比值降低（平均为3.89，而对照者为6.38微克/毫克肌酐，p = 0.0035），表位蛋白浓度也降低（分别为平均1.96和4.30微克/毫升，p = 0.0005）。
结论
尿液中表位蛋白平均水平降低可能反映了间质性膀胱炎的一个病因（上皮粘蛋白缺乏）或其结果。
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