Erickson D R, Sheykhnazari M, Ordille S, Bhavanandan V P
Department of Surgery, Pennsylvania State University College of Medicine, Hershey, USA.
J Urol. 1998 Oct;160(4):1282-4.
We compared urinary levels of hyaluronic acid in patients who met the National Institute for Diabetes, and Digestive and Kidney Diseases criteria for interstitial cystitis and in age matched healthy female controls.
Urinary hyaluronic acid was measured by solid phase radiometric assay using hyaluronic acid binding protein. Hyaluronic acid and symptom scores were compared in interstitial cystitis patients who gave multiple urine samples during treatment. Since hyaluronic acid changed with treatment in some patients, 17 samples from untreated interstitial cystitis patients were selected and compared with 17 control samples.
Mean plus or minus standard deviation urinary hyaluronic acid concentrations were similar in the 2 groups (interstitial cystitis group 574 +/- 496, controls 512 +/- 324 ng./ml., p = 0.77). When normalized to creatinine urinary hyaluronic acid was significantly higher in interstitial cystitis patients (interstitial cystitis group 674 +/- 220, controls 446 +/- 220 ng./mg. creatinine, p = 0.0019). Urinary creatinine concentrations did not differ significantly (interstitial cystitis group 842 +/- 715, controls 1,162 +/- 516 mg./l., p = 0.12).
Urinary hyaluronic acid was higher in interstitial cystitis patients than healthy controls. Since bladder hyaluronic acid is below the epithelium, this finding may indicate leakage across the epithelium into the urine in interstitial cystitis patients.
我们比较了符合美国国立糖尿病、消化和肾脏疾病研究所间质性膀胱炎标准的患者与年龄匹配的健康女性对照者的尿透明质酸水平。
使用透明质酸结合蛋白通过固相放射测定法测量尿透明质酸。对在治疗期间提供多个尿液样本的间质性膀胱炎患者的透明质酸和症状评分进行比较。由于一些患者的透明质酸随治疗而变化，因此选择了17例未经治疗的间质性膀胱炎患者的样本并与17例对照样本进行比较。
两组的平均尿透明质酸浓度（标准差）相似（间质性膀胱炎组574±496，对照组512±324 ng/ml，p = 0.77）。以肌酐进行标准化后，间质性膀胱炎患者的尿透明质酸显著更高（间质性膀胱炎组674±220，对照组446±220 ng/mg肌酐，p = 0.0019）。尿肌酐浓度无显著差异（间质性膀胱炎组842±715，对照组1162±516 mg/l，p = 0.12）。
间质性膀胱炎患者的尿透明质酸高于健康对照者。由于膀胱透明质酸位于上皮下方，这一发现可能表明间质性膀胱炎患者上皮存在渗漏至尿液中的情况。
