Edland S D, Silverman J M, Peskind E R, Tsuang D, Wijsman E, Morris J C
Department of Environmental Health, University of Washington, Seattle 98105, USA.
Neurology. 1996 Jul;47(1):254-6. doi: 10.1212/wnl.47.1.254.
This study tests the hypothesis of maternal inheritance of AD in families of 118 subjects with this disorder enrolled in The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). The parental generation included 24 subjects with dementia. Using the Cox proportional hazards model, we found the age-adjusted mother-to-father relative risk to be 2.8 (95% CI, 1.1 to 7.7). Among a subset of 10 families with one affected parent and at least two affected siblings, the ratio of affected mothers-to-fathers was 9:1. These findings support recent studies that found a high mother-to-father ratio among affected parents of subjects with AD. Together, these results suggest maternal inheritance of AD and are consistent with several hypotheses regarding the genetic nature of AD.
本研究对118名患有阿尔茨海默病（AD）的受试者家庭中AD的母系遗传假说进行了检验，这些受试者均被纳入阿尔茨海默病注册协会（CERAD）。亲代包括24名患有痴呆症的受试者。使用Cox比例风险模型，我们发现年龄调整后的母亲与父亲的相对风险为2.8（95%置信区间，1.1至7.7）。在10个有一位患病父母且至少有两个患病兄弟姐妹的家庭子集中，患病母亲与父亲的比例为9:1。这些发现支持了最近的研究，即在AD受试者的患病父母中，母亲与父亲的比例很高。总之，这些结果表明AD存在母系遗传，并且与关于AD遗传本质的几种假说一致。
