Ramachandran G, Marder K, Tang M, Schofield P W, Chun M R, Devanand D P, Stern Y, Mayeux R
Gertrude H. Sergievsky Center, New York, NY 10032, USA.
Neurology. 1996 Jul;47(1):256-9. doi: 10.1212/wnl.47.1.256.
We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations.
我们评估了46例阿尔茨海默病（AD）患者和135例载脂蛋白（APO）E3/3或E3/4基因型对照者中抑郁和精神病的发生率。与APOE3/3基因型患者或对照者相比，APOE3/4基因型的AD患者出现抑郁和精神病症状的几率增加了三倍多。我们的初步研究表明，与ε4等位基因相关的AD表型更有可能包括精神症状。
