Guizar-Sahagun G, García-López P, Espitia A L, Méndez S, Castañeda-Hernández G, Madrazo I, Franco-Bourland R E
Proyecto Camina A.C., Mexico City, Mexico.
Neurosci Lett. 1996 Mar 15;206(2-3):185-8. doi: 10.1016/s0304-3940(96)12469-1.
The expression of nitric oxide synthase in neurons of the gastrointestinal tract (GIT) after experimental spinal cord injury (SCI) was assessed in adult rats contused at T8. One day and 10 weeks after injury, specimens along the GIT were studied for NADPH-diaphorase histochemistry. A significant increase in the number of positive cell bodies and fibers in the myenteric plexus were observed 1 day after SCI, as compared to specimens from control and chronically injured rats, with the exception of the colon, which showed unchanged or decreased number of positive neurons in the acute and chronic stages, respectively. Positive neurons in the submucous plexus remained unchanged, excepting an increase in the colon after acute SCI, and a decrease in the duodenum in chronically injured rats. The altered nitric oxide neurotransmission in the GIT may be relevant to its reduced motility after SCI.
在成年T8节段挫伤的大鼠中，评估了实验性脊髓损伤（SCI）后胃肠道（GIT）神经元中一氧化氮合酶的表达。损伤后1天和10周，采用NADPH-黄递酶组织化学方法研究了沿胃肠道的标本。与对照和慢性损伤大鼠的标本相比，SCI后1天，肌间神经丛中阳性细胞体和纤维的数量显著增加，但结肠除外，结肠在急性期和慢性期阳性神经元数量分别未变或减少。黏膜下神经丛中的阳性神经元保持不变，但急性SCI后结肠中阳性神经元增加，慢性损伤大鼠十二指肠中阳性神经元减少。胃肠道中一氧化氮神经传递的改变可能与其SCI后运动性降低有关。
