Alexandrou K, Hata Y, Matsuka K, Matsuda H
Department of Plastic Surgery, Kagawa Medical School, Japan.
Scand J Plast Reconstr Surg Hand Surg. 1996 Mar;30(1):17-22. doi: 10.3109/02844319609072399.
Beraprost sodium, a chemically stable prostaglandin I2 analogue with antiplatelet vasodilator actions, was tested by comparing the extent of viability of random pattern skin flaps in control rats and rats treated with beraprost sodium. An isolated tail based 2 x 7 cm flap was constructed in 50 Sprague-Dawley rats. In group 1 (beraprost sodium treated group, n = 25) 0.015 mg beraprost sodium were injected intraperitoneally immediately after the flap had been raised. In group 2 (control group, n = 25) the animals were injected intraperitoneally with the same volume of saline immediately after the flap had been raised. At the end of the seventh day the flap survival area was documented using digital planimetry. The difference between the results showed that beraprost sodium had significantly beneficial effect on skin flap survival (p < 0.01, Welch's test).
贝拉前列素钠是一种具有抗血小板血管舒张作用的化学稳定的前列腺素I2类似物，通过比较对照组大鼠和接受贝拉前列素钠治疗的大鼠中随意型皮瓣的存活程度来进行测试。在50只Sprague-Dawley大鼠中构建了一个基于尾巴的2×7厘米的孤立皮瓣。在第1组（贝拉前列素钠治疗组，n = 25）中，皮瓣掀起后立即腹腔注射0.015毫克贝拉前列素钠。在第2组（对照组，n = 25）中，皮瓣掀起后立即给动物腹腔注射相同体积的生理盐水。在第七天结束时，使用数字平面测量法记录皮瓣存活面积。结果之间的差异表明，贝拉前列素钠对皮瓣存活具有显著的有益作用（p < 0.01，韦尔奇检验）。
