Zuo Y C, Li Y F, Liu W, Deng Y L, Huang D W, Mei L, Fan S G, Ding G F
Department of Immunology, Beijing Medical University.
Sheng Li Xue Bao. 1995 Oct;47(5):515-9.
Our previous work showed that a lymphocyte proliferation suppressing factor could be found in the serum of restraint mice. In the present work, it was found that intracerebroventricular (icv) injection of IL-1 receptor antagonist (IL-1Ra) was found capable of suppressing the production of such a serum protein under restraint stress. Nearly complete suppression could be achieved by 5.0 micrograms IL-1Ra. Intracerebroventricular injection of IL-1 beta (1 pg), however, increased the generation of the supressive protein. Neither intraperitoneal (ip) injection of IL-1Ra or IL-1 beta had any effect on the generation of the protein. The fact that icv. injection of a very small dose of IL-1 beta (0.06 fmol) was effective on the generation of the supressive protein led us to suggest that IL-1 in brain might act as an important mediator between CNS and the immune system.
我们之前的研究表明，在受到束缚的小鼠血清中可发现一种淋巴细胞增殖抑制因子。在本研究中，发现脑室内注射白细胞介素-1受体拮抗剂（IL-1Ra）能够在束缚应激状态下抑制这种血清蛋白的产生。5.0微克的IL-1Ra可实现几乎完全的抑制。然而，脑室内注射IL-1β（1皮克）会增加这种抑制性蛋白的产生。腹腔注射IL-1Ra或IL-1β对该蛋白的产生均无任何影响。脑室内注射极少量的IL-1β（0.06飞摩尔）对抑制性蛋白的产生有效这一事实使我们推测，脑中的IL-1可能是中枢神经系统与免疫系统之间的重要介质。
