Wang J X, Chen W, Mei L, Lai L, Tang H Y, Fan S G
Department of Physiology, Beijing Medical University.
Sheng Li Xue Bao. 1992 Dec;44(6):541-8.
A serum lymphocyte-proliferation suppressive factor(s) induced by restraint stress over 10 h was found in previous studies in both rats and mice. The present study was undertaken to investigate the sites of its production. The results show that large doses of irradiation and cyclophosphamide (CY) decreased the total number of splenic nucleated cells, but the production of the suppressive factor was inhibited only by irradiation. This indicates that the drop in total number of lymphocytes does not play any key role in the production of the serum suppressive factor. Cell classification showed that the ratio of T to B cell was decreased by radiation but increased by CY, suggesting that this ratio may be relevant to the production of the factor. Inhibition of the production was also observed in nude mouse (an animal showing a lack of T cell activity), again supporting that T cells are involved in the production of the inhibitory factor.
在之前针对大鼠和小鼠的研究中发现，10小时以上的束缚应激可诱导产生一种血清淋巴细胞增殖抑制因子。本研究旨在探究其产生部位。结果显示，大剂量照射和环磷酰胺（CY）可使脾有核细胞总数减少，但抑制因子的产生仅受照射抑制。这表明淋巴细胞总数的下降在血清抑制因子的产生中不起关键作用。细胞分类显示，T细胞与B细胞的比例受辐射降低，但受CY升高，提示该比例可能与因子的产生有关。在裸鼠（一种缺乏T细胞活性的动物）中也观察到了产生的抑制作用，这再次支持T细胞参与了抑制因子的产生。
