Wada Y, Wada N, Kubo M
Department of Pediatrics, Kashiwa Hospital, Tokyo Jikei University School of Medicine, Chiba, Japan.
Ryumachi. 1996 Feb;36(1):50-7.
We encountered three cases of juvenile rheumatoid arthritis which showed a depressed serum complement level during the clinical course. Circulating immune complex and increased secondary fibrinolysis were detected in all cases. The laboratory data suggested the presence of vesculitis. Cutaneous vasculitis was observed by biopsy in 2 cases and abnormal respiratory function in one cases. These 3 cases were in contrast to other 95 JRA cases treated in our department who showed normal serum complement levels. Estimation of serum complement may, therefore be useful to predict the vascular complication and refractoriness to therapy in JRA.
我们遇到了3例青少年类风湿性关节炎患者，他们在临床过程中血清补体水平降低。所有病例均检测到循环免疫复合物和继发性纤维蛋白溶解增加。实验室数据提示存在血管炎。2例经活检观察到皮肤血管炎，1例呼吸功能异常。这3例与我科治疗的其他95例血清补体水平正常的青少年类风湿性关节炎病例形成对比。因此，血清补体的评估可能有助于预测青少年类风湿性关节炎的血管并发症和治疗难治性。
