Siassi F, Wang M, Kopple J D, Swendseid M E
Am J Physiol. 1977 May;232(5):E526-8. doi: 10.1152/ajpendo.1977.232.5.E526.
Brain serotonin turnover was investigated in chronically uremic and sham-operated pair-fed control rats. Animals were injected ip with 100 mg/kg body wt of pargyline HCl, a nonreversible monoamine oxidase inhibitor, and decapitated 0, 30 and 60 min later. The level of total tryptophan in plasma was decreased, and that of free tryptophan was increased in the uremic group. Uremic and control rats had similar concentrations of tryptophan and serotonin at 0 and 30 min after pargyline administration. However, the brain serotonin concentration was elevated in the uremic group 60 min after pargyline treatment. The brain serotonin turnover rate was higher and serotonin turnover time was lower in the uremic group. These results indicate that uremic stress, in addition to altering plasma tryptophan levels, also affects brain serotonin turnover.
对慢性尿毒症大鼠和假手术配对喂养的对照大鼠的脑血清素周转率进行了研究。给动物腹腔注射100mg/kg体重的盐酸帕吉林（一种不可逆的单胺氧化酶抑制剂），并在0、30和60分钟后断头。尿毒症组血浆中总色氨酸水平降低，游离色氨酸水平升高。在给予帕吉林后0和30分钟，尿毒症大鼠和对照大鼠的色氨酸和血清素浓度相似。然而，在给予帕吉林60分钟后，尿毒症组的脑血清素浓度升高。尿毒症组的脑血清素周转率较高，血清素周转时间较短。这些结果表明，尿毒症应激除了改变血浆色氨酸水平外，还影响脑血清素周转率。
