遗传学家对复杂疾病的研究方法。

The geneticist's approach to complex disease.

作者信息

Ghosh S, Collins F S

机构信息

National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892-2152, USA.

出版信息

Annu Rev Med. 1996;47:333-53. doi: 10.1146/annurev.med.47.1.333.

DOI:10.1146/annurev.med.47.1.333

PMID:8712786

Abstract

Many studies are in progress worldwide to elucidate the genetics of complex diseases. Nevertheless, few articles are available that provide the scientific rationale and give guidelines for such ambitious endeavours. We describe the methodology and background necessary to study the genetics of complex disease and discuss how to analyze the data. We also provide a table of some ongoing studies. In particular, we wish to emphasize the analysis of intermediate, heritable, quantitative traits as a means of dissecting the genetic basis of a complex trait.

摘要

全球范围内正在进行许多研究以阐明复杂疾病的遗传学。然而，很少有文章能提供此类宏伟研究的科学依据并给出指导方针。我们描述了研究复杂疾病遗传学所需的方法和背景，并讨论了如何分析数据。我们还提供了一些正在进行的研究的表格。特别地，我们希望强调对中间的、可遗传的定量性状进行分析，以此作为剖析复杂性状遗传基础的一种手段。