Jones M A, Silman A J, Whiting S, Barrett E M, Symmons D P
ARC Epidemiology Research Unit, University of Manchester, United Kingdom.
Ann Rheum Dis. 1996 Feb;55(2):89-93. doi: 10.1136/ard.55.2.89.
To determine the risk of rheumatoid arthritis (RA) in first degree relatives of a true population based sample of probands with inflammatory polyarthritis.
In a case-control study, a two stage screening procedure was used to ascertain the prevalence of RA in 518 first degree relatives of 207 Norfolk Arthritis Register cases registered in 1990 and 414 first degree relatives of 180 local controls. An initial joint symptom and medical history questionnaire was followed by a physical examination, and serological and radiological evaluation of those with symptoms.
The prevalence of RA in the first degree relatives of all the Norfolk Arthritis Register cases was 7.7/1000, compared with 4.8/1000 in the first degree relatives of the controls, with a risk ratio of 1.6 (95% confidence interval 0.3 to 8.7). This very modest increase was also seen when the analysis was restricted to the first degree relatives of Norfolk Arthritis Register cases who satisfied the American Rheumatism Association criteria for RA: prevalence rate 7.2/1000.
There was no evidence of an important increased familial risk of RA in this community based sample. These data are compatible with others from immunogenetic studies showing only weak HLA associations with community ascertained RA.
在一个基于真实人群的炎性多关节炎先证者样本中，确定其一级亲属患类风湿关节炎（RA）的风险。
在一项病例对照研究中，采用两阶段筛查程序，以确定1990年登记的207例诺福克关节炎登记病例的518名一级亲属以及180名本地对照的414名一级亲属中RA的患病率。首先进行关节症状和病史问卷调查，随后对有症状者进行体格检查、血清学和影像学评估。
所有诺福克关节炎登记病例的一级亲属中RA患病率为7.7/1000，而对照的一级亲属中患病率为4.8/1000，风险比为1.6（95%置信区间0.3至8.7）。当分析仅限于符合美国风湿病协会RA标准的诺福克关节炎登记病例的一级亲属时，也观察到这种非常适度的增加：患病率为7.2/1000。
在这个基于社区的样本中，没有证据表明RA的家族风险有重要增加。这些数据与免疫遗传学研究的其他数据一致，这些研究表明HLA与社区确诊的RA仅有微弱关联。
