社区新诊断病例中HLA-DRB1*04与类风湿关节炎之间不存在关联。
Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community.
作者信息
Thomson W, Pepper L, Payton A, Carthy D, Scott D, Ollier W, Silman A, Symmons D
机构信息
ARC Epidemiology Research Unit, Manchester Medical School, United Kingdom.
出版信息
Ann Rheum Dis. 1993 Jul;52(7):539-41. doi: 10.1136/ard.52.7.539.
Abstract
OBJECTIVES
To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis.
METHODS
HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis.
RESULTS
The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%).
CONCLUSIONS
The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.
摘要
目的
确定一系列新诊断的早期炎症性关节炎患者中HLA - DR4和DR1等位基因频率。
方法
通过对208例分类为类风湿关节炎（RA）或未分化炎症性多关节炎患者进行寡核苷酸分型来确定HLA - DR1和DR4频率。
结果
这些RA患者中DR4的出现频率与英国对照组相比无显著差异（42%对37%）。炎症性多关节炎组中HLA - DR1增加（25%对18%）。
结论
新诊断的社区RA患者中DR4频率未增加。这支持了以下假设，即DR4作为RA易感性标志物的重要性低于其对疾病持续或严重程度的重要性。
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