Yurdakul S, Tüzüner N, Yurdakul I, Hamuryudan V, Yazici H
Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey.
Ann Rheum Dis. 1996 Mar;55(3):208-10. doi: 10.1136/ard.55.3.208.
To make a retrospective and prospective analysis of the frequency of symptomatic inflammatory bowel disease in patients with Behçet's syndrome (BS).
The medical records of the first 1000 patients with BS were reviewed retrospectively for past or present history of diarrhoea. The past and present history of diarrhoea was also elicited prospectively among 147 consecutive patients with BS and 78 diseased controls (42 with rheumatoid arthritis, 17 with systemic lupus erythematosus, seven with seronegative spondylarthropathy, and 12 with miscellaneous rheumatic diseases). Inflammatory mucosal changes were sought in rectal biopsy specimens from 75 patients with BS, 47 diseased controls (29 with nephrotic syndrome, eight with rheumatoid arthritis, six with familial Mediterranean fever, and four with ankylosing spondylitis), and 14 patients with ulcerative colitis.
In chart review there were only seven Behçet's patients with diarrhoea; none of them had inflammatory bowel disease. In the prospective survey there were no significant differences between the BS and control groups in the past and present history of diarrhoea. There were no significant differences in the rectal mucosal histology between patients with BS and controls, while patients with ulcerative colitis showed pronounced differences.
Symptomatic inflammatory bowel disease is not common in BS patients from Turkey.
对贝赫切特综合征（BS）患者中症状性炎症性肠病的发生率进行回顾性和前瞻性分析。
回顾性查阅前1000例BS患者的病历，了解其既往或目前的腹泻病史。同时前瞻性调查147例连续性BS患者以及78例疾病对照者（42例类风湿关节炎患者、17例系统性红斑狼疮患者、7例血清阴性脊柱关节病患者以及12例其他风湿性疾病患者）的既往和目前腹泻病史。对75例BS患者、47例疾病对照者（29例肾病综合征患者、8例类风湿关节炎患者、6例家族性地中海热患者以及4例强直性脊柱炎患者）以及14例溃疡性结肠炎患者的直肠活检标本进行炎症性黏膜改变检查。
病历回顾中仅有7例贝赫切特综合征患者有腹泻症状；他们均无炎症性肠病。在前瞻性调查中，BS组与对照组在既往和目前腹泻病史方面无显著差异。BS患者与对照者的直肠黏膜组织学无显著差异，而溃疡性结肠炎患者则表现出明显差异。
在来自土耳其的BS患者中，症状性炎症性肠病并不常见。
