Moyana T N, Kulaga A, Xiang J
Department of Pathology, Royal University Hospital, Saskatoon, Canada.
Arch Pathol Lab Med. 1996 Feb;120(2):203-5.
The incidence of systemic candidiasis appears to be on the rise, and unusual or hitherto undocumented clinicopathologic features of invasive candidiasis continue to be described. This report adds further to this spectrum by describing granulomatous appendicitis due to invasive candidiasis. The patient was a 23-year-old woman with acute promyelocytic leukemia. Her other risk factors included the use of aggressive chemotherapy, immunosuppressives, broadspectrum antibiotics, and invasive instrumentation. In view of the acquired immunodeficiency syndrome epidemic, as well as the improved survival of patients with prolonged neutropenia owing to better intensive care units, there is reason to believe that other as yet undocumented clinicopathologic manifestations of invasive candidiasis or other opportunistic infections may come to light.
系统性念珠菌病的发病率似乎在上升，侵袭性念珠菌病不寻常的或迄今尚无记录的临床病理特征不断被描述。本报告通过描述侵袭性念珠菌病所致的肉芽肿性阑尾炎，进一步丰富了这一范畴。患者为一名23岁的急性早幼粒细胞白血病女性。她的其他危险因素包括使用强化化疗、免疫抑制剂、广谱抗生素以及侵入性器械操作。鉴于获得性免疫缺陷综合征的流行，以及由于重症监护病房条件改善，中性粒细胞减少持续时间延长的患者生存率提高，有理由相信侵袭性念珠菌病或其他机会性感染的其他尚未有记录的临床病理表现可能会被发现。
