Pochettino A, Anderson D R, Hammond R L, Spanta A D, Hohenhaus E, Niinami H, Huiping L, Ruggiero R, Hooper T L, Baars M
Division of Cardiothoracic Surgery, Wayne State University, School of Medicine, Detroit, Michigan.
J Card Surg. 1991 Mar;6(1 Suppl):145-53. doi: 10.1111/jocs.1991.6.1s.145.
Our most recent work on cardiac assist with canine latissimus dorsi muscle in a skeletal muscle ventricle (SMV) configuration is reported here. One animal's SMV has been pumping blood effectively in the circulation for more than 16 months. To date there is no evidence of thromboembolism, and the dog has suffered no untoward effects. It has recently been shown, in a mock circulation study, that canine SMVs are capable of developing stroke work, at physiological preloads, much greater than that of the right ventricle and equivalent to that of the left ventricle. The improved ability of conditioned SMVs to perform work, independent of the circulation, during severe hypotension is also demonstrated. In the face of a 75% drop in left ventricular stroke work, the SMV stroke work dropped by only 50%. The continuing work on this subject suggests that a skeletal muscle ventricle may have the potential of becoming a viable alternative in the treatment of heart failure.
本文报道了我们最近关于采用骨骼肌心室（SMV）构型的犬背阔肌进行心脏辅助的研究工作。一只动物的SMV已在循环系统中有效泵血超过16个月。迄今为止，没有血栓栓塞的迹象，且这只狗未出现任何不良影响。最近在一项模拟循环研究中表明，犬类SMV在生理预负荷下能够产生的每搏功，比右心室大得多，且与左心室相当。同时也证明了，经过训练的SMV在严重低血压期间独立于循环系统进行工作的能力有所提高。面对左心室每搏功下降75%的情况，SMV的每搏功仅下降了50%。关于该主题的持续研究表明，骨骼肌心室可能有潜力成为治疗心力衰竭的一种可行替代方案。
