Konishi H, Antaki J F, Litwak P, Kameneva M, Yamazaki K, Macha M, Kerrigan J P, Mandarino W A, Butler K C, Borovetz H S, Kormos R L
University of Pittsburgh, Artificial Heart and Lung Program, School of Medicine, Pennsylvania, USA.
Artif Organs. 1996 Feb;20(2):124-7. doi: 10.1111/j.1525-1594.1996.tb00713.x.
We are developing an axial flow blood pump with Nimbus Inc. (AxiPump). For in vivo evaluation the AxiPump has been used as a left ventricular assist device with a left ventricular and descending aorta cannulation and implantation in a small pocket on the left lateral abdominal wall just posterior to the costal margin. Electrical and flow probe leads exit the body transcutaneously. A purge line that delivers the purge fluid for lubrication of the seal between the rotor and stator bodies in the purge fluid bearing system is tunneled with the other leads. Following acute animal studies, 3 animals have been supported for over 1 month with this AxiPump system. All laboratory results were within normal limits except during a recovery period from surgical damage. Hemolysis was not a serious problem. In the first case, the purge system failed at 28 days, and in the second and third cases, the nonpurge bearing system worked well for 57 and 52 days, respectively. Bearings are still under development in this kind of pump. However, this success encourages us to improve the AxiPump as a long-term assist device.
我们正在与Nimbus公司合作开发一款轴流血泵（AxiPump）。为了进行体内评估，AxiPump已被用作左心室辅助装置，通过左心室和降主动脉插管，并植入肋缘后方左侧腹壁的一个小口袋中。电气和流量探头导线经皮引出体外。一根输送清洗液的清洗管线，用于润滑清洗液轴承系统中转子和定子主体之间的密封，与其他导线一起通过隧道引出体外。经过急性动物研究后，有3只动物使用该AxiPump系统得到了超过1个月的支持。除了手术损伤后的恢复期外，所有实验室结果均在正常范围内。溶血不是一个严重问题。在第一个病例中，清洗系统在28天时出现故障，在第二个和第三个病例中，非清洗轴承系统分别正常工作了57天和52天。这种类型的泵的轴承仍在研发中。然而，这一成功鼓励我们将AxiPump改进为一种长期辅助装置。
