Yamada T, Nishimura K, Park C H, Kono S, Yuasa S, Tsukiya T, Akamatsu T, Matsuda K, Ban T
Department of Cardiovascular Surgery, Kyoto University, Japan.
Artif Organs. 1997 Jul;21(7):635-8. doi: 10.1111/j.1525-1594.1997.tb03713.x.
We have been developing a new type of centrifugal pump for long-term use. The magnetically suspended centrifugal pump (MSCP) contains no shaft and seal so that long life expectancy is predicted. Paracorporeal left ventricular (LV) assist circulation between the left atrium and the descending aorta was instituted using sheep. The flow rates ranged from 2.5-5.5 L/min. The sheep that lived the longest (46 days) died of an embolism as a result of the thrombus in the pump. No thrombus formation was observed in other pumps. Plasma free hemoglobin levels ranged from 9 to 18 mg/dl, which led to the conclusion that the hemolysis level remained within an acceptable range. Two driving modes were compared. The slope of the pressure-flow relationship plot under a constant motor current mode was steeper than that under a constant rotational speed mode, and thus, the flow fluctuation decreased. In conclusion, the MSCP is durable for more than a month at the current stage of development and is a promising device for long-term ventricular assist.
我们一直在研发一种新型的长期使用的离心泵。磁悬浮离心泵（MSCP）没有轴和密封，因此预计使用寿命长。使用绵羊建立了左心房和降主动脉之间的体外左心室（LV）辅助循环。流速范围为2.5-5.5升/分钟。存活时间最长的绵羊（46天）死于泵内血栓形成导致的栓塞。在其他泵中未观察到血栓形成。血浆游离血红蛋白水平范围为9至18毫克/分升，由此得出溶血水平仍在可接受范围内的结论。比较了两种驱动模式。在恒定电机电流模式下压力-流量关系图的斜率比在恒定转速模式下更陡，因此流量波动减小。总之，在当前的研发阶段，磁悬浮离心泵可持续使用一个多月，是一种有前景的长期心室辅助装置。
