Draca S
Institute of Neurology, Clinical Centre of Serbia, Belgrade, Yugoslavia.
Immunol Cell Biol. 1995 Dec;73(6):481-3. doi: 10.1038/icb.1995.77.
Prolactin (PRL), an endocrine hormone from the anterior pituitary, is also synthesized and secreted by activated immunocytes, mostly T cells and thymocytes. In vitro PRL acts as an autocrine or paracrine growth factor which regulates the proliferation of previously stimulated immunocompetent cells. PRL acts through its specific cell surface receptors expressed on different immunocytes including T cells, B cells, monocytes, NK cells and neutrophils. In vivo the immunoregulatory role of PRL is still the subject of intense investigation, especially in the conditions of stress and reproduction. The conflicting results suggest that PRL concentration, sex hormones and some other factors influence the immunomodulatory role of PRL.
催乳素（PRL）是一种来自垂体前叶的内分泌激素，也由活化的免疫细胞合成和分泌，主要是T细胞和胸腺细胞。在体外，PRL作为一种自分泌或旁分泌生长因子，调节先前受刺激的免疫活性细胞的增殖。PRL通过其在包括T细胞、B细胞、单核细胞、NK细胞和中性粒细胞在内的不同免疫细胞上表达的特异性细胞表面受体发挥作用。在体内，PRL的免疫调节作用仍是深入研究的课题，尤其是在应激和生殖条件下。相互矛盾的结果表明，PRL浓度、性激素和其他一些因素会影响PRL的免疫调节作用。
