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[通过将致癌病毒DNA显微注射到黑腹果蝇早期胚胎的极质中获得的突变基因座的分子克隆]

[Molecular cloning of mutant loci obtained by microinjection of oncogenic viral DNA into polar plasma of early embryos of Drosophila melanogaster].

作者信息

Soldatov A V, Nabirochkin S D

出版信息

Genetika. 1996 Feb;32(2):192-6.

PMID:8713619
Abstract

Mutations WRSV-1 and WRSV-4 obtained by microinjection of RSV cDNA into early embryos of Drosophila melanogaster were shown to be caused by the insertion of mobile elements jockey and B104(roo), respectively partial reversion of WRSV-lr arose due to the deletion of a 5'-region of mobile element jockey and of the adjacent region of the genomic DNA. It is concluded that genetic instability induced by oncoviral DNAs is based on the ability of these DNAs to induce transpositions of various mobile elements in the recipient genome.

摘要

通过将劳斯肉瘤病毒（RSV）cDNA显微注射到黑腹果蝇早期胚胎中获得的突变WRSV-1和WRSV-4，分别被证明是由移动元件jockey和B104（roo）的插入引起的，WRSV-1r的部分回复是由于移动元件jockey的5'区域和基因组DNA的相邻区域缺失所致。得出的结论是，肿瘤病毒DNA诱导的遗传不稳定性基于这些DNA诱导受体基因组中各种移动元件转座的能力。

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