85氪在大鼠再生肝脏中的溶解度。
The solubility of 85Krypton in the regenerating liver of the rat.
作者信息
Mathie R T, Leiberman D P, Harper A M, Blumgart L H
出版信息
Br J Exp Pathol. 1977 Jun;58(3):231-5.
The accuracy of liver blood flow measurement using the 85Krypton clearance technique depends on the use of an appropriate value for the solubility of 85Kr in liver relative to blood (the partition coefficient, lambda). This factor was studied in the regenerating liver remnant of the rat after a 67% partial hepatectomy, in order to find the influence of the ensuing postoperative fatty infiltration of the liver. There was found to be a rapid increase in lambda from 0-95 in the normal liver to 1-52 in the remnant 7-5 h after operation, followed by a more gradual return to normal levels by 35 h. The results indicate an early increase in the fat content of the liver after 67% hepatectomy and demonstrate that liver blood flow calculated from 85Kr clearance measurements in the early stages of regeneration must take into account the changes in lambda during that time.
使用氪-85清除技术测量肝脏血流的准确性取决于采用一个合适的氪-85在肝脏相对于血液中的溶解度值（分配系数，λ）。为了探究术后肝脏随之出现的脂肪浸润的影响，对大鼠行67%肝部分切除术后再生的肝残体中的这个因素进行了研究。结果发现，λ值从正常肝脏中的0.95迅速升至术后7.5小时肝残体中的1.52，随后在35小时时更逐渐地恢复至正常水平。结果表明，67%肝切除术后肝脏脂肪含量早期增加，并且表明在再生早期根据氪-85清除测量计算的肝脏血流必须考虑这段时间内λ值的变化。
Zotero 插件