使用氪85清除技术测量大鼠肝脏血流量。
Measurement of liver blood flow in the rat using an 85Krypton clearance technique.
作者信息
Rice G C, Ryan C J, Leiberman D P, Mathie R T, McGhee E, Harper A M, Blumgart L H
出版信息
Br J Exp Pathol. 1977 Jun;58(3):236-42.
Abstract
A method for the measurement of liver blood flow (LBF) in rats has been developed by recording the clearance of 85Kr from the liver after injection of a solution of the gas into the portal vein. This technique provides a measure of tissue perfusion at a cellular level. The animal preparation was maintained in a stable haemodynamic and respiratory state for up to 4-3 h by careful fluid and anaesthetic control. Stability of the model was reflected by relative constancy of the LBF measured throughout the experiment in all of the animals studied. The mean LBF determined in six rats was 2-41+/-(s.d.) 0-50 ml/g/min.
摘要
通过记录将气态85Kr溶液注入门静脉后其从肝脏的清除情况，已开发出一种测量大鼠肝脏血流量（LBF）的方法。该技术可在细胞水平上测量组织灌注。通过仔细的液体和麻醉控制，动物制剂在长达4至3小时内保持稳定的血流动力学和呼吸状态。在所有研究的动物中，整个实验过程中测量的LBF相对恒定，这反映了模型的稳定性。在六只大鼠中测定的平均LBF为2.41±（标准差）0.50 ml/g/min。
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Measurement of liver blood flow in the rat using an 85Krypton clearance technique.使用氪85清除技术测量大鼠肝脏血流量。
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