使用氪85清除技术测量大鼠肝脏血流量。
Measurement of liver blood flow in the rat using an 85Krypton clearance technique.
作者信息
Rice G C, Ryan C J, Leiberman D P, Mathie R T, McGhee E, Harper A M, Blumgart L H
出版信息
Br J Exp Pathol. 1977 Jun;58(3):236-42.
Abstract
A method for the measurement of liver blood flow (LBF) in rats has been developed by recording the clearance of 85Kr from the liver after injection of a solution of the gas into the portal vein. This technique provides a measure of tissue perfusion at a cellular level. The animal preparation was maintained in a stable haemodynamic and respiratory state for up to 4-3 h by careful fluid and anaesthetic control. Stability of the model was reflected by relative constancy of the LBF measured throughout the experiment in all of the animals studied. The mean LBF determined in six rats was 2-41+/-(s.d.) 0-50 ml/g/min.
摘要
通过记录将气态85Kr溶液注入门静脉后其从肝脏的清除情况，已开发出一种测量大鼠肝脏血流量（LBF）的方法。该技术可在细胞水平上测量组织灌注。通过仔细的液体和麻醉控制，动物制剂在长达4至3小时内保持稳定的血流动力学和呼吸状态。在所有研究的动物中，整个实验过程中测量的LBF相对恒定，这反映了模型的稳定性。在六只大鼠中测定的平均LBF为2.41±（标准差）0.50 ml/g/min。
相似文献
1
Measurement of liver blood flow in the rat using an 85Krypton clearance technique.使用氪85清除技术测量大鼠肝脏血流量。
Br J Exp Pathol. 1977 Jun;58(3):236-42.
2
Liver tissue blood flow measured by 85Kr clearance in the anaesthetized rat before and after partial hepatectomy.通过在部分肝切除术前和术后对麻醉大鼠进行⁸⁵氪清除率测量来测定肝组织血流量。
Br J Exp Pathol. 1977 Jun;58(3):243-50.
3
Liver blood flow measurements in the portacavally transposed rat before and after partial hepatectomy.门静脉-腔静脉转位大鼠部分肝切除前后的肝血流测量
Br J Exp Pathol. 1978 Apr;59(2):111-5.
4
The solubility of 85Krypton in the regenerating liver of the rat.85氪在大鼠再生肝脏中的溶解度。
Br J Exp Pathol. 1977 Jun;58(3):231-5.
5
Hepatic blood flow studies in the rat before and after portacaval transposition.大鼠门腔静脉转位前后的肝血流研究。
Br J Exp Pathol. 1978 Feb;59(1):8-12.
6
[Measurement of hepatic blood flow by krypton 85 injections in portal vein and hepatic artery].
C R Seances Soc Biol Fil. 1973;167(8):1319-20.
7
8
New method for measurement of hepatic blood flow in the rat using thermodilution method.使用热稀释法测量大鼠肝血流量的新方法。
Circ Shock. 1987;21(1):31-7.
9
Determination of the specific blood flow of the liver by inhalation of radioactive rare gases.通过吸入放射性稀有气体测定肝脏的特定血流量。
Acta Hepatogastroenterol (Stuttg). 1975 Jun;22(3):150-8.
10
Hepatic blood flow and cardiac output after porta-caval anastomosis in the rat.
Acta Hepatogastroenterol (Stuttg). 1976 Feb;23(1):31-40.
引用本文的文献
1
A quality assurance protocol for reliable and reproducible multi-TI arterial spin labeling perfusion imaging in rat livers.大鼠肝脏中用于可靠且可重复的多TI动脉自旋标记灌注成像的质量保证方案。
MAGMA. 2025 Jan 4. doi: 10.1007/s10334-024-01223-1.
2
Liver perfusion MRI in a rodent model of cirrhosis: Agreement with bulk-flow phase-contrast MRI and noninvasive evaluation of inflammation in chronic liver disease using flow-sensitive alternating inversion recovery arterial spin labelling and tissue T1.肝硬化啮齿动物模型中的肝脏灌注 MRI：与体素内不相干运动磁共振成像的一致性，以及利用流动敏感交替反转恢复动脉自旋标记和组织 T1 对慢性肝病进行非侵入性炎症评估。
NMR Biomed. 2021 Feb;34(2):e4423. doi: 10.1002/nbm.4423. Epub 2020 Oct 7.
3
Hepatic arterial spin labelling MRI: an initial evaluation in mice.肝动脉自旋标记磁共振成像：在小鼠中的初步评估
NMR Biomed. 2015 Feb;28(2):272-80. doi: 10.1002/nbm.3251. Epub 2014 Dec 17.
4
Changes in liver blood flow after hepatectomy in conscious dogs.清醒犬肝切除术后肝血流的变化。
Surg Today. 1996;26(9):688-93. doi: 10.1007/BF00312085.
5
Radioxenon washout from the dog liver: a comparison of portal venous and hepatic arterial injections.
Pflugers Arch. 1980 Mar;384(1):75-81. doi: 10.1007/BF00589518.
6
Measurement of hepatic blood flow in the rat using fractional clearance of indocyanine green and colloidal radiogold.
Pflugers Arch. 1981 Oct;391(4):353-4. doi: 10.1007/BF00581523.
7
Pharmacokinetics of 5-fluorouracil infusions in the rat: comparison with man and other species.
Cancer Chemother Pharmacol. 1985;14(2):108-11. doi: 10.1007/BF00434346.
8
Liver blood flow measurements in the portacavally transposed rat before and after partial hepatectomy.门静脉-腔静脉转位大鼠部分肝切除前后的肝血流测量
Br J Exp Pathol. 1978 Apr;59(2):111-5.
9
Hepatic blood flow studies in the rat before and after portacaval transposition.大鼠门腔静脉转位前后的肝血流研究。
Br J Exp Pathol. 1978 Feb;59(1):8-12.
10
Activated charcoal haemoperfusion via an extracorporeal circuit in the unrestrained and unanaesthetized rat.在未束缚、未麻醉的大鼠中通过体外循环进行活性炭血液灌流。
Br J Exp Pathol. 1979 Aug;60(4):400-10.
本文引用的文献
1
THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN.人体肝血流量的估计
J Clin Invest. 1945 Nov;24(6):890-7. doi: 10.1172/JCI101676.
2
Hemodynamic changes in the hepatectomized liver of the rat and their relationship to regeneration.大鼠肝切除术后肝脏的血流动力学变化及其与肝再生的关系。
J Surg Res. 1963 Jan;3:3-8. doi: 10.1016/s0022-4804(63)80071-2.
3
Measurement of hepatic blood flow by bromsulphalein and by the electromagnetic flowmeter.用溴磺酞钠和电磁流量计测量肝血流量。
Surgery. 1960 Dec;48:1017-21.
4
The measurement of local cortical blood flow in the brain by the analysis of the clearance curve of krypton-85.通过分析氪-85的清除曲线来测量大脑局部皮质血流量。
Phys Med Biol. 1961 Jul;6:65-71. doi: 10.1088/0031-9155/6/1/305.
5
6
7
Fate of radioactive kryton (Kr85) introduced intravenously in man.
J Appl Physiol. 1959 Jan;14(1):63-6. doi: 10.1152/jappl.1959.14.1.63.
8
Measurement of hepatic blood flow by indicator dilution techniques.通过指示剂稀释技术测量肝血流量。
J Clin Invest. 1958 Dec;37(12):1848-56. doi: 10.1172/JCI103777.
9
The measurement of liver blood flow in partially hepatectomized rats.部分肝切除大鼠肝脏血流的测量
J Physiol. 1957 Apr 30;136(2):287-93. doi: 10.1113/jphysiol.1957.sp005759.
10
Liver blood flow measured by portal venous and hepatic arterial routes with Kr-85.用氪-85通过门静脉和肝动脉途径测量肝血流量。
Am J Physiol. 1966 May;210(5):926-32. doi: 10.1152/ajplegacy.1966.210.5.926.
Zotero 插件