Jackson C W, Edwards C C
Br J Haematol. 1977 May;36(1):97-105. doi: 10.1111/j.1365-2141.1977.tb05759.x.
Appropriate low dosages of vincristine stimulate megakaryocytopoiesis and produce thrombocytosis. In this study of the thrombocytotic action of vincristine, administration of a single dose of 0.1 mg/kg to rats produced an increase in megakaryocyte concentration, diameter and 24 h [3H]thymidine labelling index. Transfusion of one body equivalent of platelets from normal donors prevented stimulation of megakaryocytopoiesis by vincristine whereas platelets from vincristine-treated donors did not. These results suggest that vincristine stimulates megakaryocytopoiesis by altering the functional role of circulating platelets in the regulation of thrombopoiesis.
适当低剂量的长春新碱可刺激巨核细胞生成并导致血小板增多。在这项关于长春新碱促血小板生成作用的研究中，给大鼠单次注射0.1 mg/kg的长春新碱后，巨核细胞浓度、直径及24小时[3H]胸腺嘧啶核苷标记指数均增加。输入相当于一个体当量的正常供体血小板可阻止长春新碱对巨核细胞生成的刺激作用，而输入经长春新碱处理的供体的血小板则无此作用。这些结果表明，长春新碱通过改变循环血小板在血小板生成调节中的功能作用来刺激巨核细胞生成。
