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本文引用的文献

1
SCREEN FILTRATION PRESSURE METHOD AND ADHESIVENESS AND AGGREGATION OF BLOOD CELLS.筛滤压力法与血细胞的黏附性和聚集性
J Appl Physiol. 1964 Mar;19:340-6. doi: 10.1152/jappl.1964.19.2.340.
2
Effects of adenosine analogues and of heparin on platelet thrombi in non-lipaemic and lipaemic rats.腺苷类似物和肝素对非脂血和脂血大鼠血小板血栓的影响。
Br J Exp Pathol. 1965 Dec;46(6):569-76.
3
Effects of colchicine and vinca alkaloids on human platelets. 3. Influence on primary internal contraction and secondary aggregation.秋水仙碱和长春花生物碱对人血小板的作用。3. 对原发性内收缩和继发性聚集的影响。
Am J Pathol. 1969 Mar;54(3):467-78.
4
Effects of colchicine and Vinca alkaloids on human platelets. I. Influence on platelet microtubules and contractile function.秋水仙碱和长春花生物碱对人血小板的作用。I. 对血小板微管和收缩功能的影响。
Am J Pathol. 1968 Aug;53(2):281-91.
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Acute intravascular haemolysis and platelet behaviour.
Nature. 1968 May 18;218(5142):696-7. doi: 10.1038/218696a0.
6
The effect of vincristine on the platelet count in rats.
Br J Haematol. 1970 Sep;19(3):331-7. doi: 10.1111/j.1365-2141.1970.tb01630.x.
7
Method to determine the degree of ADP-induced platelet aggregation in circulating rat blood ("filter-loop technique").测定循环大鼠血液中ADP诱导血小板聚集程度的方法（“滤环技术”）
Br J Haematol. 1970 Sep;19(3):321-9. doi: 10.1111/j.1365-2141.1970.tb01629.x.
8
Energy metabolism, body size, and problems of scaling.
Fed Proc. 1970 Jul-Aug;29(4):1524-32.
9
The effect of aspirin on in vivo platelet function in humans.阿司匹林对人体体内血小板功能的影响。
Thromb Res. 1976 Jun;8(6):797-801. doi: 10.1016/0049-3848(76)90008-6.
10
Evidence that stimulation of megakaryocytopoiesis by low dose vincristine results from an effect on platelets.低剂量长春新碱刺激巨核细胞生成是由其对血小板的作用所致的证据。
Br J Haematol. 1977 May;36(1):97-105. doi: 10.1111/j.1365-2141.1977.tb05759.x.

采用滤膜圈技术在大鼠中研究长春新碱对血小板聚集的影响。

The effects of vincristine on platelet aggregation studied by a filter loop technique in the rat.

作者信息

Bee D, Leach E, Martin J F, Suggett A J

出版信息

Br J Pharmacol. 1980 Jun;69(2):227-31. doi: 10.1111/j.1476-5381.1980.tb07894.x.

DOI:10.1111/j.1476-5381.1980.tb07894.x
PMID:7437636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044252/
Abstract

1 A method for measuring aggregation of platelets of adenosine diphosphate (ADP) is described using a filter inserted into the flowing aortic blood in the rat. 2 Repeated infusions of ADP resulted in a fall in the calculated aggregation index without significant changes in the platelet count. 3 Vincristine (0.05 mg/kg) intravenously caused significant inhibition of ADP-induced platelet aggregation. 4 Infusion of ADP caused some peripheral vasodilatation though it is unlikely that this contributed to the effects seen to any great extent.

摘要
  1. 描述了一种使用插入大鼠主动脉流动血液中的滤器来测量二磷酸腺苷（ADP）诱导的血小板聚集的方法。2. 重复输注ADP导致计算出的聚集指数下降，而血小板计数无显著变化。3. 静脉注射长春新碱（0.05mg/kg）可显著抑制ADP诱导的血小板聚集。4. 输注ADP引起了一些外周血管舒张，尽管这不太可能在很大程度上导致所观察到的效应。