采用滤膜圈技术在大鼠中研究长春新碱对血小板聚集的影响。
The effects of vincristine on platelet aggregation studied by a filter loop technique in the rat.
作者信息
Bee D, Leach E, Martin J F, Suggett A J
出版信息
Br J Pharmacol. 1980 Jun;69(2):227-31. doi: 10.1111/j.1476-5381.1980.tb07894.x.
Abstract
1 A method for measuring aggregation of platelets of adenosine diphosphate (ADP) is described using a filter inserted into the flowing aortic blood in the rat. 2 Repeated infusions of ADP resulted in a fall in the calculated aggregation index without significant changes in the platelet count. 3 Vincristine (0.05 mg/kg) intravenously caused significant inhibition of ADP-induced platelet aggregation. 4 Infusion of ADP caused some peripheral vasodilatation though it is unlikely that this contributed to the effects seen to any great extent.
摘要
- 描述了一种使用插入大鼠主动脉流动血液中的滤器来测量二磷酸腺苷（ADP）诱导的血小板聚集的方法。2. 重复输注ADP导致计算出的聚集指数下降，而血小板计数无显著变化。3. 静脉注射长春新碱（0.05mg/kg）可显著抑制ADP诱导的血小板聚集。4. 输注ADP引起了一些外周血管舒张，尽管这不太可能在很大程度上导致所观察到的效应。
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