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[使用免疫调节剂增强对实验性脊髓灰质炎的疫苗后免疫力]

[The use of immunomodulators to enhance postvaccinal immunity to experimental poliomyelitis].

作者信息

Bondarenko V I, Zadorozhnaia V I, Buraia T A, Gritsenko L N

出版信息

Mikrobiol Z. 1995 Nov-Dec;57(6):41-5.

PMID:8714398
Abstract

A possibility to use immunostimulator dibasole and methyluracil to increase [correction of decrease] the level of neutralising antibodies to polioviruses [correction of polyviruses] of types I, II, III in response to immunization by the alive poliomyelitis vaccine was studied in experiments on rabbits. The higher level of immune response when using the mentioned drugs, especially methyluracil, has been established; repeated immunization is needed to develop antibodies to poliovirus [correction of polyavirus] of type III.

摘要

在兔实验中研究了使用免疫刺激剂双嘧达莫和甲基尿嘧啶来提高[纠正“降低”]对I、II、III型脊髓灰质炎病毒[纠正“多病毒”]的中和抗体水平以应对口服脊髓灰质炎活疫苗免疫的可能性。已确定使用上述药物尤其是甲基尿嘧啶时免疫反应水平更高;需要重复免疫才能产生针对III型脊髓灰质炎病毒[纠正“多病毒”]的抗体。

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