Khan S R
Department of Pathology, College of Medicine, University of Florida, Gainesville 32610, USA.
Scanning Microsc. 1995 Jun;9(2):597-614; discussion 614-6.
It is generally recognized that calcium oxalate crystal formation in urine is induced by heterogeneous nucleation. However, there is no consensus as to the nature of the nucleation substrate. Evidence is provided in this paper that membranous cellular degradation products are the most likely candidates because they: (1) are ubiquitous in urine and urinary stones; (2) are found in close association with crystal deposits in the kidneys; and (3) can induce nucleation of crystals from a metastable solution of calcium oxalate in vitro and metastable urine in vivo.
人们普遍认为，尿液中草酸钙晶体的形成是由异相成核诱导的。然而，关于成核底物的性质尚无共识。本文提供的证据表明，膜性细胞降解产物最有可能是成核底物，因为它们：(1) 在尿液和尿结石中普遍存在；(2) 与肾脏中的晶体沉积物紧密相关；(3) 能够在体外从草酸钙亚稳溶液中以及在体内从亚稳尿液中诱导晶体成核。
