Orme M L, Lewis P J, de Swiet M, Serlin M J, Sibeon R, Baty J D, Breckenridge A M
Br Med J. 1977 Jun 18;1(6076):1564-5. doi: 10.1136/bmj.1.6076.1564.
Warfarin was measured with a sensitive and specific method in the plasma and breast milk of 13 mothers. Less than 0-08 micronmol warfarin per litre (25 ng/ml) of breast milk was found in each instance. Seven of the mothers were breast-feeding their infants, in none of whom was warfarin detected in the plasma; furthermore, in three the British corrected ratio of the plasma was appreciably less than that of the mother and was within the expected range. We conclude that nursing mothers given warfarin may safely breast-feed their infants.
采用灵敏且特异的方法检测了13位母亲血浆和母乳中的华法林。每次母乳中检测到的华法林含量均低于每升0.08微摩尔（25纳克/毫升）。7位母亲在母乳喂养婴儿，其婴儿血浆中均未检测到华法林；此外，其中3位母亲血浆的英国校正比值明显低于其自身，且处于预期范围内。我们得出结论，服用华法林的哺乳期母亲可以安全地母乳喂养婴儿。
