Pynoos R S, Ritzmann R F, Steinberg A M, Goenjian A, Prisecaru I
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles 90024, USA.
Biol Psychiatry. 1996 Jan 15;39(2):129-34. doi: 10.1016/0006-3223(95)00088-7.
The purpose of this study was to evaluate an animal model of posttraumatic stress disorder (PTSD) in mice. The model featured repeated exposures to situational reminders of a traumatic stress, which consisted of a brief electric shock, and included assessment of two behavioral parameters and the startle reflex. The findings indicated an initial, but unsustained, increase in locomotor activity in a neutral environment due to traumatic stress. Exposure to situational reminders was associated with a persistent bidirectional abnormal behavioral pattern in a fear-provoking environment and a progressive increase over time in the magnitude of the startle reflex. Exposure to situational reminders also produced an increase in aggressive behavior. This animal model appears to produce behavioral changes analogous to those seen in patients with PTSD.
本研究的目的是评估小鼠创伤后应激障碍（PTSD）的动物模型。该模型的特点是反复暴露于创伤性应激的情境提示中，创伤性应激由一次短暂电击组成，并且包括对两个行为参数和惊跳反射的评估。研究结果表明，由于创伤性应激，在中性环境中运动活动最初会增加，但这种增加并不持久。在引发恐惧的环境中，暴露于情境提示与持续的双向异常行为模式相关，并且随着时间的推移惊跳反射的幅度会逐渐增加。暴露于情境提示还会导致攻击行为增加。这种动物模型似乎产生了与PTSD患者类似的行为变化。
