肝脏药物乙酰化和氧化：衰老对人体的影响。
Hepatic drug acetylation and oxidation: effects of aging in man.
作者信息
Farah F, Taylor W, Rawlins M D, James O
出版信息
Br Med J. 1977 Jul 16;2(6080):155-6. doi: 10.1136/bmj.2.6080.155.
Abstract
The half lives of acetanilide and isoniazid ("model" substrates for oxidation and acetylation respectively) were measured in populations of young (aged 20-35 years) and elderly (aged over 65 years) people. Whereas acetanilide half lives were significantly longer in the elderly, isoniazid half lives were distributed similarly in both populations. The results suggest that liver function does not decline uniformly with age and that heterozygotes for acetylation do not possess survival advantages during their middle years of life.
摘要
在年轻人群（20 - 35岁）和老年人群（65岁以上）中测量了乙酰苯胺和异烟肼（分别作为氧化和乙酰化的“模型”底物）的半衰期。乙酰苯胺的半衰期在老年人中显著更长，而异烟肼的半衰期在这两个人群中的分布相似。结果表明，肝功能不会随年龄均匀下降，并且乙酰化杂合子在中年时期并不具有生存优势。
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本文引用的文献
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Gerontol Clin (Basel). 1968;10(1):43-57.
3
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