乙酰苯胺处置过程中的年龄相关差异。
Age related differences in the disposition of acetanilide.
作者信息
Playfer J R, Baty J D, Lamb J, Powell C, Price-Evans D A
出版信息
Br J Clin Pharmacol. 1978 Dec;6(6):529-33. doi: 10.1111/j.1365-2125.1978.tb00878.x.
Abstract
1 The metabolism of fifteen elderly hospital in-patients and fifteen young people was studied, using a gas chromatography mass spectrometer method. 2 The results suggest that there is no significant change in hepatic oxidation of acetanilide with age. 3 The concentrations of metabolites were however, significantly elevated in the older group. 4 These results illustrate the importance of the decline in renal function with age in the disposition of drugs.
摘要
- 采用气相色谱 - 质谱联用仪方法，对15名老年住院患者和15名年轻人的新陈代谢进行了研究。2. 结果表明，随着年龄增长，对乙酰氨基酚的肝脏氧化作用没有显著变化。3. 然而，老年组代谢物的浓度显著升高。4. 这些结果说明了随着年龄增长肾功能下降在药物代谢中的重要性。
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