Gitter A H
Department of Neurobiology, University of Muenster, Germany.
ORL J Otorhinolaryngol Relat Spec. 1996 Jan-Feb;58(1):1-3. doi: 10.1159/000276785.
In a geometric model of passive elastic elements in the hair bundles of vertebrate acousticolateralis hair cells, Geisler provides evidence against a role of horizontal links in sensory transduction. One premise of this model, the tenet that horizontal links are stretched in the same way as tip links, may be invalid. We propose that the horizontal links may be rigid, implying that the attachment points of the horizontal links in the stereociliary membrane must move when the hair bundle is deflected. Since the movement is linear with the angle of deflection, a connection of transduction channels and horizontal links is conceivable.
在脊椎动物听侧线毛细胞毛束中被动弹性元件的几何模型中,盖斯勒提供了证据反驳水平连接在感觉转导中的作用。该模型的一个前提,即水平连接与顶端连接以相同方式被拉伸的原则,可能是无效的。我们提出水平连接可能是刚性的,这意味着当毛束发生偏转时,水平连接在静纤毛膜中的附着点必定会移动。由于这种移动与偏转角呈线性关系,转导通道与水平连接之间的联系是可以想象的。