糖尿病神经病变中的乙酰化酶表型
Acetylator phenotype in diabetic neuropathy.
作者信息
McLaren E H, Burden A C, Moorhead P J
出版信息
Br Med J. 1977 Jul 30;2(6082):291-3. doi: 10.1136/bmj.2.6082.291.
Abstract
The proportions of slow and fast acetylators in a group of diabetics with symptomatic peripheral neuropathy were compared with those in a group of diabetics who had had the disease for at least 10 years without developing neuropathy. There was a significantly higher proportion of fast acetylators in the group of diabetics without neuropathy than in those with neuropathy or in the normal population. Hence genetic factors separate from the diabetic diathesis may determine the development of neuropathy in any particular diabetic.
摘要
将一组有症状性周围神经病变的糖尿病患者中慢乙酰化者和快乙酰化者的比例，与一组患糖尿病至少10年但未发生神经病变的糖尿病患者的比例进行了比较。在未发生神经病变的糖尿病患者组中，快乙酰化者的比例显著高于发生神经病变的糖尿病患者组或正常人群。因此，独立于糖尿病素质的遗传因素可能决定任何特定糖尿病患者神经病变的发生。
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本文引用的文献
1
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2
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3
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4
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J Pathol. 1971 Jul;104(3):175-84. doi: 10.1002/path.1711040304.
5
Isoniazid neuropathy in man: quantitative electron microscope study.人类异烟肼神经病变：定量电子显微镜研究
Brain. 1970;93(4):831-50. doi: 10.1093/brain/93.4.831.
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