Nakamura M, Nagamine N, Takahashi T, Norimatsu M, Suzuki S, Sato S
National Veterinary Assay Laboratory, Tokyo, Japan.
Avian Dis. 1995 Oct-Dec;39(4):853-8.
The tissue distribution of Salmonella enteritidis in intratracheally inoculated chickens and the effect of deprivation of food and water on tissue distributions of the bacteria have been investigated. Seven-week-old specific-pathogen-free chickens were inoculated intratracheally with 10(2), 10(5), or 10(8) cells and orally with 10(5) cells. The intratracheally inoculated organisms entered the blood stream immediately after inoculation and produced generalized infection. Infection by the intratracheal route resulted in colonization of S. enteritidis in the cecum that was similar to infection by the oral route. The tissue distribution of S. enteritidis was markedly affected when chickens were deprived of food and water for a short time, demonstrating an increased susceptibility of chickens to S. enteritidis infection. This suggests that stresses such as food and water deprivation are one of of the causes of the rapid dissemination of S. enteritidis among chickens in poultry houses.
研究了肠炎沙门氏菌在经气管接种的鸡体内的组织分布，以及禁食和禁水对该细菌组织分布的影响。将7周龄的无特定病原体鸡经气管接种10²、10⁵或10⁸个菌细胞，并经口接种10⁵个菌细胞。经气管接种的细菌在接种后立即进入血流并引发全身性感染。经气管途径感染导致肠炎沙门氏菌在盲肠定植，这与经口途径感染相似。当鸡短时间禁食和禁水时，肠炎沙门氏菌的组织分布受到显著影响，表明鸡对肠炎沙门氏菌感染的易感性增加。这表明禁食和禁水等应激因素是肠炎沙门氏菌在家禽舍鸡群中快速传播的原因之一。
