Koyama K, Furukawa Y, Tanaka H
Department of Urology, Kawasaki Medical School, Kurashiki, Japan.
Scand J Urol Nephrol. 1995 Dec;29(4):483-90. doi: 10.3109/00365599509180031.
One hundred and four patients with multiple primary malignant neoplasm (MPN) with at least one genitourinary organ involved were analyzed. The 104 patients represented 0.9% of all cancer patients and 9.0% of all urologic tumor cases. Tumors of the prostate and bladder in urologic cancers and tumors of the gastrointestinal tract, particularly stomach cancer, in non-urologic cancers were predominantly involved. In 79 cases (76.0%), the second tumors were discovered within 5 years from the diagnosis of the first cancer. Renal cell carcinoma tended to be discovered incidentally and concomitantly. In contrast, bladder cancer tended to be an initial primary tumor presenting with symptoms, and tumor of prostate tended to be found incidentally, as a second cancer in metachronous cancer associations. All second tumors of the liver were found incidentally with ultrasonographic examination after a small interval. Strict follow-up at regular intervals at least the initial 5 years are essential for the detection of second malignant neoplasms.
对104例至少累及一个泌尿生殖器官的多原发性恶性肿瘤（MPN）患者进行了分析。这104例患者占所有癌症患者的0.9%，占所有泌尿系统肿瘤病例的9.0%。泌尿系统癌症中的前列腺癌和膀胱癌以及非泌尿系统癌症中的胃肠道肿瘤，尤其是胃癌，受累最为常见。在79例（76.0%）患者中，第二个肿瘤是在第一个癌症诊断后的5年内发现的。肾细胞癌往往是偶然发现且同时存在。相比之下，膀胱癌往往是出现症状的初始原发性肿瘤，而前列腺肿瘤往往是偶然发现的，作为异时性癌症关联中的第二种癌症。所有肝脏的第二个肿瘤都是在短时间间隔后通过超声检查偶然发现的。至少在最初的5年进行定期严格随访对于发现第二种恶性肿瘤至关重要。
