Rodriguez M, Barroso N
Department of Physiology, University of La Laguna, Tenerife, Canary Islands, Spain.
Brain Res. 1995 Dec 12;703(1-2):201-4. doi: 10.1016/0006-8993(95)01098-x.
In the present paper, the action of beta-phenylethylamine on electrophysiological activity of dopaminergic nigrostriatal neurons is described. 10 s after its i.v. injection and during 2-4 min, beta-phenylethylamine decreased the firing rate, the number of spikes within and out of burst and the number of bursts per second of these neurons. This was a dose-related action with statistical differences starting from 1.4 mg/kg for total and out of burst firing rate and from 2.4 mg/kg for within burst firing rate and for the number of bursts per second. The standard deviation and the variation coefficient of inter-spike intervals increased in a dose-related way. The marked effect found after low-dose administration suggests that under physiological conditions endogenous beta-phenylethylamine levels regulate the nigrostriatal dopaminergic cell activity. After peripheral low dose administration, beta-phenylethylamine behaves as a dopaminergic agonist with a very fast and brief action.
在本论文中，描述了β-苯乙胺对多巴胺能黑质纹状体神经元电生理活动的作用。静脉注射后10秒以及在2 - 4分钟内，β-苯乙胺降低了这些神经元的放电频率、爆发内和爆发外的尖峰数量以及每秒的爆发次数。这是一种剂量相关的作用，对于总放电频率和爆发外放电频率，从1.4毫克/千克开始具有统计学差异，对于爆发内放电频率和每秒爆发次数，从2.4毫克/千克开始具有统计学差异。峰间间隔的标准差和变异系数以剂量相关的方式增加。低剂量给药后发现的显著效果表明，在生理条件下内源性β-苯乙胺水平调节黑质纹状体多巴胺能细胞的活性。外周低剂量给药后，β-苯乙胺表现为一种作用非常快速且短暂的多巴胺能激动剂。
